刘海鹏
博士
教授
Dr.
Liu Haipeng
Professor
Tel:
0592-2183203
Fax:
Email:
haipengliu@xmu.edu.cn
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个人履历
Brief CV
- 瑞典乌普萨拉大学，博士 （2008.9）
- 厦门大学，副教授 （2008.11－2012.7）
厦门大学，教授 （2012.8-）
- PhD, Uppsala University, Sweden （Sept.2008）
- Associate Professor, Xiamen University (Nov.2008-Jul.2013)；Professor, Xiamen University (Aug.2012-present)
研究方向
Research Interests
- Molecular Biology in Marine Animals；Innate Immunity in Aquaculture
代表性论文
Selected Publications
- Liu HP, Jiravanichpaisal P, Cerenius L, Lee BL,Söderhäll I and Söderhäll K. Phenoloxidase Is an Important Component of the Defense against Aeromonas hydrophila Infection in a Crustacean, Pacifastacus leniusculus. J. Biol. Chem. 2007, 282(46),33593-33598.
- Liu HP, Jiravanichpaisal P, Söderhäll I, Cerenius L, Söderhäll l K. Antilipopolysaccharide factor interferes with white spot syndrome virus replication in vitro and in vivo in the crayfish Pacifastacus leniusculus. J. Virology. 2006 80 (21) 10365-10371.
- Liu HP, Söderhäll K, Jiravanichpaisal P. Antiviral immunity in crustaceans.
Fish Shellfish Immunol. 2009 Aug;27(2):79-88.
- Liu HP, Chen FY, Gopalakrishnan S, Qiao K, Bo J, Wang KJ. Antioxidant enzymes from the crab Scylla paramamosain: Gene cloning and gene/protein expression profiles against LPS challenge. Fish Shellfish Immunol. 2010 28:862-871
- Liu HP*, Chen RY, Zhang M, Wang KJ. Isolation, gene cloning and expression
profile of a pathogen recognition protein: A serine proteinase homolog (Sp-SPH) involved in the antibacterial response in the crab Scylla paramamosain. Dev Comp Immunol. 2010. 34(7):741-748
- Liu HP, Wu C, Matsuda Y, Kawabata SI, Lee BL, Söderhäll K, Söderhäll IPeptidoglycan activation of the proPO-system without a peptidoglycan receptor protein (PGRP)? Dev Comp Immunol. 2011.35(1): 51-61
- Liu HP*, Chen RY, Zhang QX, Wang KJ. Differential gene expression profile from haematopoietic tissue stem cells of red claw crayfish, Cherax quadricarinatus, in response to WSSV infection. Dev Comp Immunol. 2011.35（7）:716-724
- Hai-peng Liu*, Rong-yuan Chen, Qiu-xia Zhang, Qiao-yang Wang, Cong-ru Li, Hui Peng, Ling Cai, Chao-qun Zheng and Ke-jian Wang Characterization of two isoforms of antiliopolysacchride factors (Sp-ALFs) from the mud crab Scylla paramamosain. Fish Shellfish Immunol. 2012.33:1-10
- Zhang QX, Liu HP*, Chen RY, Shen KL, Wang KJ. Identification of a Serine Proteinase Homolog (Sp-SPH) Involved in Immune Defense in the Mud Crab Scylla paramamosain. PLoS One. 2013;8(5):e63787
- Chao-qun Zheng, Joseph Jeswin, Kai-li Shen, Meghan Lablche, Ke-jian Wang and Hai-peng Liu*. Detrimental effect of CO2-driven seawater acidification on a crustacean brine shrimp, Artemia sinica. Fish and Shellfish Immunology. 2014 In press
本科生： 细胞生物学、细胞生物学实验、分子生物学、生物化学实验
硕士生：高级分子生物学
博士后： Jeswin Joseph （出站）
博士生（在读）： 王浩，孟闯，李卫东，李东利，刘灵珂，郑树城，刘姗，王迪
博士生（已毕业）： 陈荣元（博士研究生国家奖学金）
硕士生（在读）： 高妍，许姣阳，高瑞琳
硕士生（已毕业）：硕士研究生国家奖学金（3名）：张秋霞，林凤瑜，常雪娇
郑超群，申开利，陈振，费超
主持项目：
1.国家自然科学基金：拟穴青蟹Sp-SPH蛋白致病菌模式识别特性及其抗菌机理研究（41006077，2011-2013）
2.国家自然科学基金：对虾白斑综合症病毒（WSSV）入胞机制研究（41176114，2012-2015）
3.国家自然科学基金优秀青年基金：水产免疫生物学研究（31222056，2013-2015）
4.国家自然科学基金：自噬抑制对虾白斑综合征病毒（WSSV）感染的分子机制研究（41476117，2015-2018）
5.国家自然科学基金：基于Dscam选择性适应免疫的分子机制（41676135,2017-2020）
6. 国家自然科学基金促进海峡两岸科技合作联合基金重点项目:伽马氨基丁酸受体相关蛋白介导白斑综合征病毒感染的分子机制(U1605214,2017-2020)
7.霍英东教育基金会第十三届高等院校青年教师基金基础性研究课题：自噬在WSSV侵染
螯虾造血组织干细胞中的功能研究（131077，2012-2014）
8.教育部新世纪优秀人才支持计划（NCET-10-0711，2011-2013）
9.福建省杰出青年基金：抗病毒型抗菌肽ALFs高效表达及其初步应用研究（2013J06010，2013-2015）
10.福建省科技厅重点项目：青蟹天然抗菌活性物质ALF基因工程表达与环保饲料开发（2010N0030，2010-2011）
11.福建省高校杰出青年科研人才培育计划 :拟穴青蟹生殖免疫相关抗菌基因高通量筛选（JA10002，2010-2012）
参加项目：
1.国家重点研发专项-南海重要岛礁及邻近海域生物资源评价与生态修复-重要岛礁及邻近海域浮游生物多样性及其关键生态过程（2018YFC1406501,2018.8-2021.12）
2.973计划—海水养殖动物主要病毒性疫病爆发机理与免疫防治的基础研究-对虾免疫系统对WSSV感染的响应过程与特征（2012CB114403,2012-2016）
3.海洋领域863计划-典型海洋生物重要功能基因开发与利用“对虾功能基因开发与利用”（2012AA092205，2012-2014）
本课题组招收博士后、博士、硕士生！
欢迎有志于从事海洋甲壳动物先天免疫生物学、海洋环境分子生物学与毒理学研究者加入！
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Li YY, Xie XL, Ma XY*, Liu HP*. Identification of a CqCaspase gene with antiviral activity from red claw crayfish Cherax quadricarinatus. Dev Comp Immunol. 2019,91:101-107 . doi: 10.1016/j.dci.2018.10.012
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Gao Y#, Zheng SC#, Zheng CQ, Shi YC, Xie XL, Wang KJ, Liu HP*. The immune-related fatty acids are responsive to CO2 driven seawater acidification in a crustacean brine shrimp Artemia sinica. Dev Comp Immunol. 2018. 81:342-347
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Chen XX, Li YY, Chang XJ, Xie XL, Liang YT, Wang KJ, Zheng WY*, Liu HP*. A CqFerritin protein inhibits white spot syndrome virus infection via regulating iron ions in red claw crayfish Cherax quadricarinatus. Dev Comp Immunol. 2018 Jan 16;82:104-112.
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Li DL, Chang XJ, Xie XL, Zheng SC, Zhang QX, Jia SA, Wang KJ, Liu HP*. A thymosin repeated protein1 reduces white spot syndrome virus replication in red claw crayfish Cherax quadricarinatus. Dev Comp Immunol. 2018 Feb 8;84:109-116.
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Xie XL, Chang XJ, Gao Yan, Li DL, Liu LK, Liu MJ, Wang KJ, Liu HP*. An Ns1abp-like gene promotes white spot syndrome virus infection by interacting with the viral envelope protein VP28 in red claw crayfish Cherax quadricarinatus. Dev Comp Immunol. 2018,84:264-272.
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Li YY, Chen XX, Lin FY, Chen QF, Ma XY* and Liu HP*. CqToll participates in antiviral response against white spot syndrome virus via induction of anti-lipopolysaccharide factor in red claw crayfish Cherax quadricarinatus. Dev Comp Immunol. 2017 May 4.74:217-226.
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Liu LK, Li WD, Gao Y, Chen RY, Xie XL, Hong H, Wang KJ, Liu HP*. A laminin-receptor-like protein regulates white spot syndrome virus infection by binding to the viral envelope protein VP28 in red claw crayfish Cherax quadricarinatus. Dev Comp Immunol. 2018 Feb;79:186-194.
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Chang XJ, Zheng CQ, Wang YW, Meng C, Xie XL, Liu HP*. Differential protein expression using proteomics from a crustacean brine shrimp (Artemia sinica) under CO2-driven seawater acidification. Fish Shellfish Immun. 2016 Oct 7. 58:669-77.
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Zhao MR, Meng C, Xie XL, Li CH*, Liu HP*. Characterization of microRNAs by deep sequencing in red claw crayfish Cherax quadricarinatus haematopoietic tissue cells after white spot syndrome virus infection. Fish Shellfish Immun. 2016 Nov 4. 59:469-483.
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Lin FY, Gao Y, Wang H, Zhang QX, Zeng CL, Liu HP*. Identification of an anti-lipopolysacchride factor possessing both antiviral and antibacterial activity from the red claw crayfish Cherax quadricarinatus. Fish and Shellfish Immunology. 2016,57:213-221.
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Chen RY, Shen KL, Chen Z, Fan WW, Xie XL, Meng C, Chang XJ, Zheng LB, Jeswin J, Li CH, Wang KJ, Liu HP*. White spot syndrome virus entry: multiple endocytic routes dependent on and strongly facilitated by Cq-GABARAP in a CME-dependent manner. Scientific Reports. 2016 Jul 7;6:28694
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Fan WW, Ye YF, Chen Z, Shao YN, Xie XL, Zhang WW, Liu HP*, Li CH*. Metabolic Product Response Profiles of Cherax quadricarinatus towards White Spot Syndrome Virus Infection. Dev Comp Immunol. 2016 Apr 8;61:236-241
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Jeswin J, Xie XL, Ji QL, Wang KJ, Liu HP*. Proteomic analysis by iTRAQ in hematopoietic stem cells from red claw crayfish Cherax quadricarinatus at both early and late stages of infection by white spot syndrome virus. Fish and Shellfish Immunology. 2016, 50:288-296
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Zheng C-q, Jeswin J, Shen K-l, Lablche M, Wang K-j, Liu HP*, Detrimental effect of CO2-driven seawater acidification on a crustacean brine shrimp, Artemia sinica, Fish and Shellfish Immunology 2015, 43:181-190
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Zhang QX, Liu HP*, Chen RY, Shen KL, Wang KJ. Identification of a Serine Proteinase Homolog (Sp-SPH) Involved in Immune Defense in the Mud Crab Scylla paramamosain. PLoS One. 2013 May 28;8(5):e63787.
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Liu H-p*, Chen R-y, Zhang Q-x, Wang Q-y, Li C-r, Peng H, Cai L, Zheng C-q, Wang K-j. Characterization of two isoforms of antiliopolysacchride factors (Sp-ALFs) from the mud crab Scylla paramamosain. Fish Shellfish Immunol. 2012 Jul;33(1):1-10.
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Liu HP*, Chen RY, Zhang QX, Wang KJ. Differential gene expression profile from haematopoietic tissue stem cells of red claw crayfish, Cherax quadricarinatus, in response to WSSV infection. Dev Comp Immunol. 2011 Mar 17.35（7）:716-724
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Liu HP, Wu C, Matsuda Y, Kawabata SI, Lee BL, Söderhäll K, Söderhäll I.* . Peptidoglycan activation of the proPO-system without a peptidoglycan receptor protein (PGRP)? Dev Comp Immunol. 2011 Jan.35(1): 51-61
-
Liu HP*, Chen RY, Zhang M, Wang KJ. Isolation, gene cloning and expression profile of a pathogen recognition protein: A serine proteinase homolog (Sp-SPH) involved in the antibacterial response in the crab Scylla paramamosain. Dev Comp Immunol. 2010 July. 34(7):741-748.
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Liu HP, Chen FY, Gopalakrishnan S, Qiao K, Bo J, Wang KJ*. Antioxidant enzymes from the crab Scylla paramamosain: Gene cloning and gene/protein expression profiles against LPS challenge. Fish Shellfish Immunol. 2010 Jun. 28:862-871
-
Liu HP, Söderhäll K, Jiravanichpaisal P*. Antiviral immunity in crustaceans. Fish Shellfish Immunol. 2009 Aug;27(2):79-88
-
Liu HP, Jiravanichpaisal P, Cerenius L, Lee BL, Söderhäll I, Söderhäll K. Phenoloxidase is an important component of the defense against Aeromonas hydrophila Infection in a crustacean, Pacifastacus leniusculus. J Biol Chem. 2007 Nov 16;282(46):33593-8.
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Liu HP, Söderhäll I. Histone H2A as a transfection agent in crayfish hematopoietic tissue cells. Dev Comp Immunol. 2007;31(4):340-6.
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Liu HP, Jiravanichpaisal P, Söderhäll I, Cerenius L, Söderhäll K*. Antilipopolysaccharide factor interferes with white spot syndrome virus replication in vitro and in vivo in the crayfish Pacifastacus leniusculus. J Virol. 2006 Nov;80(21):10365-71.
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