陈仕玺 Shixi CHEN

陈仕玺博士

教授

厦门大学翔安校区周隆泉楼 B1-216室

Dr. Shixi CHEN

Professor

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Email: chenshixi@xmu.edu.cn

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个人履历 Brief CV

厦门大学海洋与地球学院教授博士生导师（2018-至今）
厦门大学海洋系学士（1999-2003）
厦门大学海洋系博士（2003-2009）
荷兰乌德勒支大学生物系联合培养博士（2007-2009）
香港中文大学生物系博士后（2010）
厦门大学海洋与地球学院助理教授（2011-2013）
Research Associate, Department of Biology, Chinese University of Hong Kong (2010-2011)
Ph.D, Departmen of Biology, Utrecht University, the Netherlands. (2007-2009)
Ph.D. Department of Oceanography, Xiamen University, China (2003.9-2009.10)
B.Sc., Department of Oceanography, Xiamen University, China (1999-2003)
厦门大学海洋与地球学院副教授（2013-2018）

研究方向 Research Interests

Molecular Mechanisms of Steroid Action 类固醇激素作用的分子机理
Fish Developmental Genetics 鱼类发育遗传学

已结题主持项目

1、孕酮激素诱发斑马鱼精原细胞增殖分化的机理研究。国家自然科学基金（青年科学基金项目，编号：31201977）。起止年限：2013.1-2015.12；

2、纳米银对鱼类配子发生过程的干扰机制研究。福建省自然科学基金青年创新项目。编号：2013J05029。起止年限：2013.1-2015-12；

3、海洋潮间带弹涂鱼类的生态生理适应机制。厦门大学校长基金。起止年限：2013.4-2015.12；

4、中华乌塘鳢嗅觉系统孕激素受体的表达与调控机理。教育部“留学回国人员科研启动金”。起止年限：2013.6-2015.5；

5、转基因海洋观赏鱼技术体系的构建和家系培育。厦门南方海洋研究中心。编号：14GZY019NF19。起止年限：2014-2016；

6、DHP反馈调控雌性大弹涂鱼促性腺激素表达的神经内分泌机理研究。国家自然科学基金面上项目，编号：31672628。起止年限：2017.1-2020.12；

7、大黄鱼性别分化过程中Gsdf 的表达及作用研究。福建省自然科学基金面上项目。编号：2017J01067。起止年限：2017.4-2020.4；

8、2017年，“福建省高等学校新世纪优秀人才支持计划”。；

执行中主持项目

9、性信息素诱发雄性中华乌塘鳢生殖效应的神经内分泌机制研究。国家自然科学基金面上项目，编号：41976092。起止年限：2020.1-2023.12；

10、保持大黄鱼金黄体色的新技术研发。福建省农业引导性（重点）项目。编号：2021N0001。起止年限：2021.10-2024.9；

11、大黄鱼种业创新与产业化开发。福建省种业创新与产业化工程。编号： 2021FJSCZY01。起止年限：2021.1-2025.12；

12、高抗优质大黄鱼种质创新与新品种培育。国家重点研发计划项目。编号：2022YFD2401000。起止年限：2023.1-2027.10；

13、大黄鱼体色“见”光变白的分子机制研究。国家自然科学基金区域创新发展联合基金。编号：U22A20528。起止年限：2023.1-2026.12

Ma, H., Hong, W. S., & Chen, S. X.* (2023). A progestin regulates the prostaglandin pathway in the neuroendocrine system in female mudskipper Boleophthalmus pectinirostris. The Journal of Steroid Biochemistry and Molecular Biology, 231, 106300.
Zhao, N., Jiang, K., Ge, X., Huang, J., Wu, C., & Chen, S. X. (2024). Neurotransmitter norepinephrine regulates chromatosomes aggregation and the formation of blotches in coral trout Plectropomus leopardus. Fish Physiology and Biochemistry, 1-15.
Ma, H., Yang, M. S., Zhang, Y. T., Qiu, H. T., You, X. X., Chen, S. X.*, & Hong, W. S.* (2022). Expressions of melanopsins in telencephalon imply their function in synchronizing semilunar spawning rhythm in the mudskipper Boleophthalmus pectinirostris. General and comparative endocrinology, 315, 113926.
Zhu, J., Li, H., Jing, Z. Z., Zheng, W., Luo, Y. R., Chen, S. X., & Guo, F. (2022). Robust host source tracking building on the divergent and non-stochastic assembly of gut microbiome in wild and farmed large yellow croaker.Microbiome 10, 18.
Huang J., Sun C., Liu D.T., Zhao N.N., Shavit J.A., Zhu Y.*, Chen S.X.* (2022) Nuclear Progestin Receptor–mediated Linkage of Blood Coagulation and Ovulation. Endocrinology, 163, 1-16.
Zhao, N., Ge, X., Jiang, K., Huang, J., Wei, K., Sun, C., & Chen, S. X. (2022). Ultrastructure and regulation of color change in blue spots of leopard coral trout Plectropomus leopardus. Frontiers in Endocrinology, 13, 984081.
Liu, D. T., Hong, W. S., Chen, S. X.*, & Zhu, Y.* (2020). Upregulation of adamts9 by gonadotropin in preovulatory follicles of zebrafish. Molecular and cellular endocrinology, 499:110608.
Huang, J., Zhang, T. T., Jiang, K., Hong, W. S., & Chen, S. X.* (2020). GFP expression pattern in pituitary and gonads under the control of nuclear progesterone receptor promoter in transgenic zebrafish. Developmental Dynamics, 249(11), 1365-1376.
Qiu, H., Fernandes, J. M., Hong, W., Wu, H. X., ZHANG, Y. T., Huang, S., Liu, T. T., Yu, H., Wang, Q., You, X.X. & Chen, S. X.* (2019). Paralogues from the expanded Tlr11 gene family in mudskipper (Boleophthalmus pectinirostris) are under positive selection and respond differently to LPS/poly (I: C) challenge. Frontiers in Immunology, 10, 343.
Zhang, Y. T., Hong, W. S., Qiu, H. T., Wang, Q., & Chen, S. X.* (2019). Androgen induces olfactory expression of prostaglandin E2 receptor Ep1 in the burrow-living fish Bostrychus sinensis. The Journal of steroid biochemistry and molecular biology, 188:156-165.
Han, J., Hong, W. S., Wang, Q., Zhang, T. T., & Chen, S. X.* (2019). The regulation of melanocyte-stimulating hormone on the pigment granule dispersion in the xanthophores and melanophores of the large yellow croaker (Larimichthys crocea). Aquaculture, 507:7-20
Liu, D. T., Carter, N. J., Wu, X. J., Hong, W., Chen, S. X.*, & Zhu, Y*. (2018). Progestin and nuclear progestin receptor are essential for upregulation of metalloproteinase in Zebrafish Preovulatory Follicles. Frontiers in Endocrinology, 9, 517.
Zhang, Y. T., Hong, W. S., Liu, D. T., Qiu, H. T., Zhu, Y., & Chen, S. X.* (2018). Involvement of Membrane Progestin Receptor Beta (mPRβ/Paqr8) in Sex Pheromone Progestin-Induced Expression of Luteinizing Hormone in the Pituitary of Male Chinese Black Sleeper (Bostrychus Sinensis). Frontiers in endocrinology, 9,397.
Chen, S. X.,* Yang, X. Z., Deng, Y., Huang, J., Li, Y., Sun, Q., Yu, C., Zhu, Y., Hong, W. S. (2017). Silver nanoparticles induce oocyte maturation in zebrafish (Danio rerio). Chemosphere 170, 51-60.
Zhang, Y. T., Huang, S., Qiu, H. T., Li, Z., Mao, Y., Hong, W. S.*, & Chen, S. X.* (2017). Optimal salinity for rearing Chinese black sleeper (Bostrychus sinensis) fry. Aquaculture, 476, 37-43.
Bai, J., Gong, W.D., Wang, C.L., Gao, Y.D., Hong, W.S., Chen, S.X.*, 2016. Dynamic methylation pattern of cyp19a1a core promoter during zebrafish ovarian folliculogenesis. Fish Physiol Biochem 42, 947-954
Chen, Y., Hong, W.S., Wang, Q., Chen, S.X.*, 2016. Cloning and pattern of gsdf mRNA during gonadal development in the protogynous Epinephelus akaara. Anim Reprod Sci 165, 46-55
Li, Z., Hong, W.S., Qiu, H.T., Yu, T.Z., Yang, M.S., You, X.X., Chen, S.X.*, 2016. Cloning and expression of two hepcidin genes in the mudskipper (Boleophthalmus pectinirostris) provides insights into their roles in male reproductive immunity. Fish Shellfish Immunol. 56, 239-247
Wang, C.L., Liu, D.T., Chen, W.T., Ge, W., Hong, W.S., Zhu, Y., Chen, S.X.*, 2016. Progestin increases the expression of gonadotropins in pituitaries of male zebrafish. J. Endocrinol. 230, 143-156
Zhang, Y.T., Liu, D.T., Zhu, Y., Chen, S.X.*, Hong, W.S.*, 2016. Cloning and olfactory expression of progestin receptors in the Chinese black sleeper Bostrichthys sinensis. Gen Comp Endocr 230, 87-102
Chen, Y., Hong, W.S., Wang, Q., Chen, S.X.*, 2015. Cloning and expression pattern of gsdf during the first maleness reproductive phase in the protandrous Acanthopagrus latus. Gen Comp Endocrinol 217-218, 71-80
Hong, L.Y., Hong, W.S., Zhu, W.B., Shi, Q., You, X.X., Chen, S.X.* 2014. Cloning and expression of melatonin receptors in the mudskipper, Boleophthalmus pectinirostris: Their role in synchronizing its semilunar spawning rhythm. Gen Comp Endocr 195, 138-150
Lai, X.J., Hong, W.S., Liu, F., Zhang, Y.T., Chen, S.X.*, 2014. Cloning and expression of prostaglandin E-2 receptor subtype 1 (ep (1) ) in Bostrichthys sinensis. Fish Physiol Biochem 40, 1281-1288
Chen, S. X., Bogerd, J., Schoonen, N. E., Martijn, J., de Waal, P. P., & Schulz, R. W.* (2013). A progestin (17α, 20β-dihydroxy-4-pregnen-3-one) stimulates early stages of spermatogenesis in zebrafish. General and comparative endocrinology, 185, 1-9.
Chen, S. X., Almeida, F. F., Andersson, E., Taranger, G. L., Schmidt, R., Schulz, R. W., & Bogerd, J.* (2012). Cloning, pharmacological characterization and expression analysis of Atlantic cod (Gadus morhua, L.) nuclear progesterone receptor. General and comparative endocrinology, 179(1), 71-77.
Chen, S. X., Bogerd, J., Andersson, E., Almeida, F. L., Taranger, G. L., & Schulz, R. W.* (2011). Cloning, pharmacological characterization and expression analysis of Atlantic salmon (Salmo salar L.) nuclear progesterone receptor. Reproduction, REP-10.
Chen, S. X., Bogerd, J., García-López, Á., de Jonge, H., de Waal, P. P., Hong, W. S.*, & Schulz, R. W.* (2010). Molecular cloning and functional characterization of a zebrafish nuclear progesterone receptor. Biology of reproduction, 82(1), 171-181.
Chen, S. X., Hong, W. S., Su, Y. Q., & Zhang, Q. Y. (2008). Microhabitat selection in the early juvenile mudskipper Boleophthalmus pectinirostris (L.). Journal of Fish Biology, 72(3), 585-593.
Chen, S., Hong, W., Zhang, Q., & Su, Y. (2007). Why does the mudskipper Boleophthalmus pectinirostris form territories in farming ponds?. Journal of the Marine Biological Association of the United Kingdom, 87(2), 615-619.
Wanshu, H. O. N. G., Shixi, C. H. E. N., Qiyong, Z. H. A. N. G., & Qiong, W. (2007). Reproductive ecology of the mudskipper Boleophthalmus pectinirostris. ACTA OCEANOLOGICA SINICA, 26(4), 72-81.
Chen, S., Hong, W.*, Zhang, Q., Wu, R., & Wang, Q. (2006). Rates of oxygen consumption and tolerance of hypoxia and desiccation in Chinese black sleeper (Bostrichthys sinensis) and mudskipper (Boleophthalmus pectinirostris) embryos. ACTA OCEANOLOGICA SINICA, 25(4), 91.
Chen, S., Hong, W.*, Zhou, W., & Zhang, Q. (2006). Hypoxic tolerance of Chinese black sleeper Bostrichthys sinensis embryos at heartbeat stage. Journal of the Marine Biological Association of the United Kingdom, 86(6), 1473-1476.

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