王克坚 Wang Kejian

王克坚博士

Dr. Wang Kejian

Minjiang Chair Professor

Tel: 0592-2184658

Fax:

Email: wkjian@xmu.edu.cn

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个人履历 Brief CV

中国人民解放军军需大学博士（1999）
澳大利亚悉尼大学动物健康系访问学者（1993-1994）
中国农业科学院特产研究所研究员（2000-2001）
厦门大学教授（2001-）
美国佛罗里达大学生理学与功能基因系高级访问学者 (2005-2006)
"闽江学者"特聘教授 (2009-)
PhD, Quartermaster University of PLA (1999)
Visiting Scholar, Department of Animal Health, University of Sydney, Australia (1993-1994)
Senior Principal Research Fellow, Chinese Academy of Agricultural Sciences (2000-2001)
Professor, Xiamen University (2001-)
Senior Visiting Scholar, Department of Physiology and Functional Genomics, University of Florida, USA (2005-2006)
Mingjiang chair professor, Xiamen University (2009-).

研究方向 Research Interests

海洋生物分子生物学与基因组学 (Marine Molecular Biology and Genomics )；海洋环境污染物的分子与免疫毒理学 (Molecular and Immunological Ecotoxicology Studies for the Marine Environmental Pollutants ); 转基因与基因工程（Transgenic and Genetic Engineering Studies）

代表性论文 Selected Publications

Zhou, Y., Meng, X.Y., Chen, F.Y., Xiong, M., Zhang, W.B., Ke-Jian Wang* , Newly discovered antimicrobial peptide Scyampcin44-63 from Scylla paramamosain exhibits a multitargeted candidacidal mechanism in vitro and is effective in a murine model of vaginal candidiasis, Antimicrobial Agents and Chemotherapy, 2023, aac.00022-23.
Zhang, W.B., An, Z., Bai, Y.Q., Zhou, Y., Chen, F.Y. *, Wang, K.J.* , A novel antimicrobial peptide Scyreptin1-30 from Scylla paramamosain exhibiting potential therapy of Pseudomonas aeruginosa early infection in a mouse burn wound model, Biochemical Pharmacology, 218 (2023) 115917.
Zhu X., Chen F., Li S., Peng H., Wang, K.J.*, A Novel Antimicrobial Peptide Sparanegtin Identified in Scylla paramamosain Showing Antimicrobial Activity and Immunoprotective Role In Vitro and Vivo, International Journal of Molecular Science, 2022, 23, 15.
Yang Y., Chen H.Y., Hao H., Wang K.J.*, The Anticancer Activity Conferred by the Mud Crab Antimicrobial Peptide Scyreprocin through Apoptosis and Membrane Disruption, International Journal of Molecular Science , 2022, 23, 5500.
Yang, Y., Chen, F.Y., Qiao, K., Zhang, H., Chen, H.Y., Wang, K.J.* , Two Male-Specific Antimicrobial Peptides SCY2 and Scyreprocin as Crucial Molecules Participated in the Sperm Acrosome Reaction of Mud Crab Scylla paramamosain, International Journal of Molecular Sciences, 2022, 23, 3373.
Zhu,D., Chen, F.Y., Chen, Y.C., Peng, H. and Wang, K.J.* , The Long-Term Effect of a Nine Amino-Acid Antimicrobial Peptide AS-hepc3(48-56) Against Pseudomonas aeruginosa With No Detectable Resistance, Frontiers in Cellular and Infection Microbiology ,2021.752637.
Chen, Y.C., Yang, Y., Zhang, C., Chen, H.Y., Chen, F. Y.* and Wang, K.J.* , A Novel Antimicrobial Peptide Sparamosin26–54 From the Mud Crab Scylla paramamosain Showing Potent Antifungal Activity Against Cryptococcus neoformans, Frontiers in Microbiology , 2021.746006.
Zhang, H., Yang, Y., Zhu, X.W., Liu, Y.Z., Chen, F.Y.*, Wang, K.J.* , A truncated peptide Sp-NPFin from the neuropeptide FII SpNPFII of Scylla paramamosain exhibiting potent antimicrobial activity, Aquaculture, 533 (2021) 736145.
Yin, X.H., Liu, Y., Zeb, R., Chen, F.Y., Chen, H.Y., Wang, K.J.* , The intergenerational toxic effects on offspring of medaka fish Oryzias melastigma from parental benzo[a]pyrene exposure via interference of the circadian rhythm, Environmental Pollution, 267 (2020) 115437.
Cui, Q, Chen, F.Y., Zhang, M., Peng, H., Wang, K.J.*.Transcriptomic analysis revealing hepcidin expression in Oryzias melastigma regulated through the JAK-STAT signaling pathway upon exposure to BaP, Aquatic Toxicology, 2019, 206, 134-141.
Qiu, W.H.﹡, Fang, M., Liu, J., Fu, C., Zheng, C., Chen, B., Wang, K.J.*, In vivo actions of Bisphenol F on the reproductive neuroendocrine system after long-term exposure in zebrafish, Science of the Total Environment, 2019, 665: 995-1002

指导学生：

序列姓名 年级 研究生类别学籍状态

1	黄文树	01	博士研究生	已毕业
2	杨明	03	博士研究生	已毕业
3	任洪林	04	博士研究生	已毕业
4	许婉芳	04	博士研究生	已毕业
5	薄军	05	博士研究生	已毕业
6	黄伟滨	05	博士研究生	已毕业
7	蔡晶晶	06	博士研究生	已毕业
8	彭会	06	博士研究生	已毕业
9	蔡灵	07	博士研究生	已毕业
10	曲海东	07	博士研究生	已毕业
11	陈贝	08	博士研究生	已毕业
12	丁建	08	博士研究生	已毕业
13	陈晖	08	博士研究生	已毕业
14	陈芳奕	09	博士研究生	已毕业
15	乔琨	09	博士研究生	已毕业
16	张民	10	博士研究生	已毕业
17	单忠国	11	博士研究生	已毕业
18	陈荣元	11	博士研究生	已毕业
19	王书平	11	博士研究生	已毕业
20	何艺宾	12	博士研究生	已毕业
21	崔倩	13	博士研究生	已毕业
22	马笑晚	13	博士研究生	已毕业
23	杨盈	14	博士研究生	已毕业
24	殷笑晗	15	博士研究生	已毕业
25	安哲	14	博士研究生	已毕业
26	刘杰	15	博士研究生	已毕业
27	朱德鹏	15	博士研究生	已毕业
28	李积山	16	博士研究生	已毕业
29	李美佳	16	博士研究生	已毕业
30	朱学武	16	博士研究生	已毕业
31	孙航	16	博士研究生	已毕业
32	周瑛	17	博士研究生	已毕业
33	张伟宾	17	博士研究生	已毕业
34	李双	17	博士研究生	已毕业
35	Rabia Zeb	17	博士研究生	在读
36	陈炎超	18	博士研究生	已毕业
37	孟祥玉	18	博士研究生	已毕业
38	龙苏	18	博士研究生	已毕业
39	王晓飞	19	博士研究生	已毕业
40	孟新展	19	博士研究生	在读
41	白玉麒	19	博士研究生	已毕业
42	张畅	20	博士研究生	在读
43	周真真	20	博士研究生	在读
44	段盈伊	20	博士研究生	在读
45	郑文彬	21	博士研究生	在读
46	王颖	21	博士研究生	在读
47	李焓笑	21	博士研究生	在读
48	董弦弦	22	博士研究生	在读
49	徐玉俊	23	博士研究生	在读
50	陈柔石	23	博士研究生	在读
51	王春光	02	硕士研究生	已毕业
52	魏艳	02	硕士研究生	已毕业
53	陈君慧	03	硕士研究生	已毕业
54	黄叔卓	03	硕士研究生	已毕业
55	陈慧芸	04	硕士研究生	已毕业
56	徐丹丹	06	硕士研究生	已毕业
57	张鼐	07	硕士研究生	已毕业
58	范丹青	08	硕士研究生	已毕业
59	黄晟沛	08	硕士研究生	已毕业
60	吴曼丽	09	硕士研究生	已毕业
61	刘洁	09	硕士研究生	已毕业
62	张亚群	10	硕士研究生	已毕业
63	杨冰贞	10	硕士研究生	已毕业
64	庄淑芳	11	硕士研究生	已毕业
65	乔玮	11	硕士研究生	已毕业
66	侯琳	13	硕士研究生	已毕业
67	董丽霞	13	硕士研究生	已毕业
68	熊明	13	硕士研究生	已毕业
69	张梦飞	14	硕士研究生	已毕业
70	朱可欣	14	硕士研究生	已毕业
71	张华	16	硕士研究生	已毕业
72	肖旺红	16	硕士研究生	已毕业
73	弓瑞豪	17	硕士研究生	已毕业
74	刘洋洲	17	硕士研究生	已毕业
75	刘勇	15	硕士研究生	已毕业
76	洪筱	18	硕士研究生	已毕业
77	闫娇娇	19	硕士研究生	已毕业
78	邢介婷	19	硕士研究生	已毕业
79	陈友根	20	硕士研究生	已毕业
80	刘宇斯	20	硕士研究生
81	陈柔石	20	硕士研究生	已毕业
82	蔡菲	21	硕士研究生	在读
83	李凯玥	21	硕士研究生	在读
84	何宣邑	22	硕士研究生	在读
85	颜子渊	22	硕士研究生	在读
86	高于乔	23	硕士研究生	在读
87	高婷婷	23	硕士研究生	在读
88	韦美菊	23	硕士研究生	在读
89	廖惠良	23	硕士研究生	在读

主持或参加的科研项目、平台（2005-）

国家自然科学基金联合基金重点项目，2019-2022，主持人。
厦门市海洋与渔业发展专项，2022.10-2025.09，与企业联合申报。
厦门大学平潭研究院项目，2022.7-2023.12，主持人。
福建省海洋与渔业局：福建省海洋服务与渔业高质量发展专项项目，2022.8-2023.12，主持
福建省科学技术协会：福建省海洋生物科技融合服务平台，2021.12-2022.12，主持人。
厦门市海洋与渔业发展专项：海洋科技成果转化与产业化示范项目，2020-2022，与企业联合申报。
厦门市科技局项目，2020.03-2021.12，主持人。
福建省海洋经济发展补助资金项目，2019-2021，主持人。
福建省重大专项，2017-2020，重大专项首席科学家/专题责任专家。
国家自然科学基金面上项目，2017-2020，主持人。
“海洋生物制备技术国家地方联合工程实验室”（2015-），主任
福建省首批“2011协同创新中心”——海洋生物资源开发利用协同创新中心（2013-2017），主任。
教育部“创新团队发展计划” 创新团队，海洋环境生理与毒理学研究，2009-2012，2013-2015。学科带头人之一。
国家海洋公益性行业科研专项，海洋生物功能肽类与海藻多糖降解酶的制备开发，2011-2014，首席科学家。
国家支撑计划项目-功能性肽产品的创制与应用，2013-2015，子课题主持人。
福建省海洋生物抗菌肽技术重大研发平台, 2014 --2017, 负责人。
国家自然科学基金联合基金重点项目，2013-2016，主持人。
国家自然科学基金面上项目，2013-2016，主持人。
国家自然科学基金面上项目，2012-2015，主持人。
国家“863”重点项目课题，2007-2010，第一完成人。
国家自然科学基金，2007-2009，第一完成人。
“闽江学者”特聘教授奖励计划，2009-至今。
福建省“首批海西产业人才高地创新团队领军人才”，2012-2015。
国家自然科学基金：2008-2010，主要完成人。
国家“863”课题子课题，2006-2010，主要完成人。
国家“863”项目，2002—2005，主要完成人。
福建省重大科技项目,2003—2006，第一完成人。
福建省重点科技计划项目,2008-2010，第一完成人。
福建省重点项目，2007-2010，第二完成人。
福建省发改委，2008-2010，第一完成人。
福州市科技创新计划，2006—2008，合作完成人。
厦门市科技局项目，2005-2008，第一完成人。

一、课题组简介：

抗生素耐药性问题已成为影响人类健康和动物养殖业可持续发展的重大问题。抗菌肽是一类生物体中普遍存在并具有广谱抗微生物活性的小分子多肽，在防御病原微生物中起重要作用。不同于抗生素，不易产生细菌耐药性，被科学家预为“天然抗生素”，因而是研发抗耐药性细菌、真菌的理想活性物质，抗菌肽产品的研发对于保障我国医疗、食品、养殖等多个领域的健康安全具有重大意义。

自2001年起针对抗生素滥用和细菌耐药性等严重问题，致力于海洋动物新型抗菌肽的发掘与开发利用研究，研发可替代抗生素的新型生物制品，以保障人类和动物健康。20多年来，已先后主持完成国家“863”、国家海洋公益专项、国家自然基金联合基金重点、福建省重大等40多项省部级课题；从我国多种海洋经济动物中分离鉴定出百余种新抗菌肽，其中80多种新型抗菌肽为国内外首次发现并命名，揭示不同抗菌肽的功能和机制，包括抗耐药性细菌、真菌、肿瘤、病毒等体内外活性及其免疫保护作用等，发表SCI论文130多篇，已获得国内外发明专利授权42件（其中美国授权4件）；其研究成果获得国内外多项奖项，为独立自主开发应用海洋动物抗菌肽奠定坚实基础。

为推进抗菌肽的产业化，通过不断完善新型抗菌肽基因工程的高效表达体系，在企业建立了规模化发酵生产工艺，实现了抗菌肽的低成本产业化生产；开发出高效抗细菌、真菌及病毒等不同用途的抗菌肽产品，获批我国迄今唯一的2个海洋动物抗菌肽生产应用安全证书；首次在我国创建了海洋动物抗菌肽全产业链工程体系；抗菌肽产品在畜牧水产养殖、食品、日化护肤品以及医药健康等行业具有巨大应用前景。2017年以来，海洋动物抗菌肽产品已产业化应用，已有5件国家发明专利转让企业，经济社会效益显著，成果总体达到国际领先水平。

研究成果分别获 2022年度福建省技术发明奖一等奖、2023年10月亚太海洋生物技术学会成立30多年来首次设立的 “海洋生物技术奖（学术或工业界）”、2023年11月第二十五届中国国际高新技术成果交易会优秀产品奖等奖项。其创新性成果先后在福建省科技厅官网、福建日报、海西晨报、厦门日报、厦门卫视等多家主流媒体报道，为我国海洋生物资源的高效开发利用和绿色制造，起到了引领示范作用。

Zhang, C., Chen, F.Y.*, Bai, Y.Q., Dong, X.X., Meng, X.Z., Ke-Jian Wang*, A novel antimicrobial peptide Spasin141-165 identified from Scylla paramamosain exhibiting protection against Aeromonas hydrophila infection, Aquaculture, 591(2024)741137
Meng, X.Z., Duan, Y.Y., Bai, Y.Q., Zhang, W.B., Zhang, C., Chen, F.Y.*, Ke-Jian Wang*, The antimicrobial peptide Sparamosin26–54 exhibits antiviral activity against three aquatic enveloped viruses through lipid-binding-mediated virus lysis, Aquaculture, 592(2024)741160
Bai, Y.Q., Zhang, W.B., Zheng, W.B., Meng, X.Z., Duan, Y.Y., Zhang, C., Chen, F.Y.*, Ke-Jian Wang*, A 14-amino acid cationic peptide Bolespleenin334-347 from the marine fish mudskipper Boleophthalmus pectinirostris exhibiting potent antimicrobial activity and therapeutic potential, Biochemical Pharmacology, 226(2024)116344
Sun, H., Chen, F.Y., Zhang, W.B., Huang, Y.X., Peng, H., Hao, H., Ke-Jian Wang*, Impact of captivity and natural habitats on gut microbiome in Epinephelus akaara across seasons, BMC Microbiology, (2024)24:239
Zeb, R., Yin, X.H., Chen, F.Y., Ke-Jian Wang*, Chronic exposure to environmental concentrations of benzo[a]pyrene causes multifaceted toxic effects of developmental compromise, redox imbalance, and modulated transcriptional profiles in the early life stages of marine medaka (Oryzias melastigma ), Aquatic Toxicology, 273(2024)107016
Chen, R.S., Yan, J.J., Li, S., Ke-Jian Wang, Chen, F.Y.*, Characterization of a new peritrophin homolog from Scylla paramamosain and its role in molting and immune defense, Aquaculture, 594 (2025) 741457
He, W.Y., Zhang, C., Lan, H.J., Wu, G.P., Xiong, M., Peng, H., Chen, M.*, Ke-Jian Wang*, The topical application of Sphistin12-38 in combination with sponge spicules for the acne treatment, Drug Delivery and Translational Research, 2024.
Sun, H., Wang, L.X., Chen, F.Y., Meng, X.Y., Zhang, W.B., Peng, H., Hao, H.,Chen, H.Y., Ke-Jian Wang*, The modulation of intestinal commensal bacteria possibly contributes to the growth and immunity promotion in Epinephelus akaara after feeding the antimicrobial peptide Scy-hepc, Animal Microbiome, (2024) 6:54
Sun, H., Chen, F.Y., H., Hao, Xiong, M., Peng, H.,An, Z., Ke-Jian Wang*, Benefcial efects of AMP Scy-hepc on the gut microbiota contribute to the potential growth of Larimichthys crocea, Blue Biotechnology, (2024) 1:11
Chen,Y.C., Qiu, W.L., Zhang, W.B., Zhang, J.R., Chen, R.S., Chen, F.Y. *, Wang, K.J.* , A Novel Antimicrobial Peptide Sp-LECin with Broad-Spectrum Antimicrobial Activity and Anti-Pseudomonas aeruginosa Infection in Zebrafish，International Journal of Molecular Sciences, 2023, 24, 267.
An, Z., Chen, F.Y., Hao, H., Xiong, M., Peng, H., Sun, H., Wang, K.J.* , Growth- promoting effect of antimicrobial peptide Scy-hepc on mariculture large yellow croaker Larimichthys crocea and the underlying mechanism, Fish & Shellfish Immunology, 2023,108649.
Long, S., Chen, F.Y., Li, J.S., Yang,Y., Wang, K.J.* , A New Gene SCY3 Homologous to Scygonadin Showing Antibacterial Activity and a Potential Role in the Sperm Acrosome Reaction of Scylla paramamosain，International Journal of Molecular Sciences, 2023,24, 5689.
Meng, X.Y., Chen, F.Y., Xiong, M., Hao, H., Wang, K.J.*, A new pathogenic isolate of Kocuria kristinae identified for the first time in the marine fish Larimichthys crocea, Frontiers in Microbiology, 2023.1129568
Zhou, Y., Meng, X.Y., Chen, F.Y., Xiong, M., Zhang, W.B., Ke-Jian Wang* , Newly discovered antimicrobial peptide Scyampcin44-63 from Scylla paramamosain exhibits a multitargeted candidacidal mechanism in vitro and is effective in a murine model of vaginal candidiasis, Antimicrobial Agents and Chemotherapy, 2023
Li, S., Li, W.,F., Chen, F.Y., Zhu, X.,W., Chen., H.Y., Hao, H., Wang, K.J.* , Metabolomic and transcriptomic analysis reveals immune and hormone modulation at the molting stage of juvenile mud crabs challenged with Staphylococcus aureus and Vibrio alginolyticus，Aquaculture, 575 (2023) 739775.
Zhang, W.B., An, Z., Bai, Y.Q., Zhou, Y., Chen, F.Y. *, Wang, K.J.* , A novel antimicrobial peptide Scyreptin1-30 from Scylla paramamosain exhibiting potential therapy of Pseudomonas aeruginosa early infection in a mouse burn wound model, Biochemical Pharmacology, 218 (2023) 115917.
Li, W.F., Li, S., Liu, J., Wang, X.F., Chen, H.Y., Hao, H. and Wang K.J.*, Internal carbohydrates and lipids as reserved energy supply in the pubertal molt of Scylla paramamosain, Aquaculture, 2022, 23, 15.
Zhu X.W., Chen, F.Y., Li, S., Peng H., Wang K.J.*, A Novel Antimicrobial Peptide Sparanegtin Identified in Scylla paramamosain Showing Antimicrobial Activity and Immunoprotective Role In Vitro and Vivo, International Journal of Molecular Sciences, 2022, 23, 15.
Li, J.S., Qiu, W.L., Hao, H., Chen, F.Y., Wang K.J.*, Morphology of the complete embryonic and larval development of commercially important mud crab Scylla paramamosain , Aquaculture Research, 2022, 53: 2298–2316.
Yang, Y., Chen, F.Y., Qiao, K., Zhang, H., Chen, H.Y., Wang K.J.*, Two Male-Specific Antimicrobial Peptides SCY2 and Scyreprocin as Crucial Molecules Participated in the Sperm Acrosome Reaction of Mud Crab Scylla paramamosain, International Journal of Molecular Sciences, 2022, 23, 3373.
Yang Y., Chen H.Y., Hao H., Wang K.J.*, The Anticancer Activity Conferred by the Mud Crab Antimicrobial Peptide Scyreprocin through Apoptosis and Membrane Disruption, Int. J. Mol. Sci., 2022,23,5500.
Long, S., Chen, F.Y., Wang K.J.*, Characterization of two new Scygonadin homologous SCY4 and SCY5 in Scylla Paramamosain, Aquaculture, 559 (2022) 738428.
Wang, X. F., Hong, X., Chen, F.Y., Wang, K.J. *, A truncated peptide Spgillcin177–189 derived from mud crab Scylla paramamosain exerting multiple antibacterial activities, Frontiers in Cellular and Infection Microbiology, 2022, 8, 928220.
Sun, H., Chen,F.Y., Hao, H., Wang, K.J.* , Multi-dimensional investigation and distribution characteristics analysis of gut microbiota of different marine fish in Fujian Province of China, Frontiers in Microbiology ,2022.918191.
Gong, R.H.#, An, Z.#, Zhang, W.B., Chen, F.Y., Wang, K.J.* , The Antimicrobial Peptide LJ‐hep2 from Lateolabrax japonicus Exerting Activities against Multiple Pathogenic Bacteria and Immune Protection In Vivo, Marine Drugs, 2022, 20, 651.
Jiang, M.Y., Chen R.S., Zhang, J.R., Chen, F.Y. *, Wang, K.J.* , A Novel Antimicrobial Peptide Spampcin56–86 from Scylla paramamosain Exerting Rapid Bactericidal and Anti-Biofilm Activity In Vitro and Anti-Infection In Vivo, International Journal of Molecular Sciences, 2022, 23,13316.
Jiang, M.Y., Chen, R.S., Chen, F.Y.*, Zhu, X.W., Wang K.J. , A New Crustin Gene Homolog SpCrus8 Identified in Scylla paramamosain Exerting In Vivo Protection Through Opsonization and Immunomodulation, Frontiers in Immunology, 2022, 13: 946227.
Dong, M., Wang, W.L., Wang, L.L., Liu, Y., Ma., Y.W., Li, M. j., Liu, H.P., Wang, K.J. , Song, L.S.*, The characterization of an agranulocyte-specific marker (CgCD9) in the Pacific oyster Crassostrea gigas, Fish and Shellfish Immunology, 2022.06.067
Chen, J.C., Fang, C., Zheng, R.H., Chen M.L., Kim, D.H., Lee, Y.H., Bailey, C., Wang, K.J. , Lee, J.S., Bo, J.*, Environmentally relevant concentrations of microplastics modulated the immune response and swimming activity, and impaired the development of marine medaka Oryzias melastigma larvae, Ecotoxicology and Environmental Safety, 2022.113843
Zhang, H., Yang, Y., Zhu, X.W., Liu, Y.Z., Chen, F.Y.*, Wang K.J.*, A truncated peptide Sp-NPFin from the neuropeptide FII SpNPFII of Scylla paramamosain exhibiting potent antimicrobial activity, Aquaculture, 533 (2021) 736145.
Long, S., Chen, F.Y.*, Wang K.J., Characterization of a new homologous anti-lipopolysaccharide factor SpALF7 in mud crab Scylla paramamosain. Aquaculture, 534 (2021) 736333.
Zhu, D.P., Chen, F.Y., Chen, Y.C., Peng, H. and Wang K.J.*, The Long-Term Effect of a Nine Amino-Acid Antimicrobial Peptide AS-hepc3(48-56) Against Pseudomonas aeruginosa With No Detectable Resistance, Frontiers in Cellular and Infection Microbiology, 2021, 11, 752637.
Chen, Y.C., Yang, Y., Zhang, C., Chen, H.Y., Chen, F. Y.* and Wang K.J.*, A Novel Antimicrobial Peptide Sparamosin26–54 From the Mud Crab Scylla paramamosain Showing Potent Antifungal Activity Against Cryptococcus neoformans, Frontiers in Microbiology, 2021, 12, 746006.
Li, W.F., Li, S., Liu, J., Wang, X.F., Chen, H.Y., Hao, H. and Wang K.J.*, Vital Carbohydrate and Lipid Metabolites in Serum Involved in Energy Metabolism during Pubertal Molt of Mud Crab (Scylla paramamosain), Metabolites, 2021, 11, 651.
Li, M.J., Dong, M.R., Wang, W.L., Li, H., Liu, Z.Q., Wang, L.L.,Wang K.J., Song, L.S.*, A membrane-bound dopamine β-hydroxylase highly expressed in granulocyte of Pacific oyster Crassostrea gigas, Developmental and Comparative Immunology, 104 (2020) 103563.
Liu, S., Pan, C.Y., Tang, Y., Chen, F.Y., Yang, M. *, Wang K.J., Identification of novel long non-coding RNAs involved in bisphenol A induced immunotoxicity in fish primary macrophages, Fish and Shellfish Immunology, 2020, 100: 152-160.
Yang, Y., Chen, F.Y., Chen, H.Y., Peng, H., Hao, H.,Wang K.J.*, A novel antimicrobial peptide scyreprocin from mud crab Scylla paramamosain showing potent antifungal and anti-biofilm activity, Frontiers in Microbiology, 2020, 11, 01589.
Yin, X.H., Liu, Y., Zeb, R., Chen, F.Y., Chen, H.Y., Wang K.J.*, The intergenerational toxic effects on offspring of medaka fish Oryzias melastigma from parental benzo[a]pyrene exposure via interference of the circadian rhythm, Environmental Pollution, 267 (2020) 115437.
Li, J.S., Dong, L.X., Zhu, D.P., Zhang, M., Wang K.J., Chen, F.Y.*, An effector caspase Sp-caspase first identified in mud crab Scylla paramamosain exhibiting immune response and cell apoptosis. Fish and Shellfish Immunology, 2020, 103: 442-453.
Liu, J., Chen, F.Y., Wang, X.F., Peng, H., Zhang, H.,Wang K.J.*, The Synergistic Effect of Mud Crab Antimicrobial Peptides Sphistin and Sph12−38 With Antibiotics Azithromycin and Rifampicin Enhances Bactericidal Activity Against Pseudomonas Aeruginosa, Frontiers in Cellular and Infection Microbiology, 2020, 10, 572849.
Liu, L.K., Gao, R.L., Gao, Y., Xu, J.Y., Guo, L.M. Wang K.J., Liu, H.P.*, A histone K-lysine acetyltransferase CqKAT2A-like gene promotes white spot syndrome virus infection by enhancing histone H3 acetylation in red claw crayfish Cherax quadricarinatus. Developmental and Comparative Immunology, 107 (2020) 103640.
Gao, Y., Liu, L.K., Wang K.J., Liu, H.P.*, A negative elongation factor E inhibits white spot syndrome virus replication by suppressing promoter activity of the viral immediate early genes in red claw crayfish Cherax quadricarinatus, Developmental and Comparative Immunology, 107 (2020) 103665.
Liu, L.K., Chen, X.X., Gao, R.L., Wang K.J.., Zheng, W.Y., Liu, H.P.*, A cytokine receptor domeless promotes white spot syndrome virus infection via JAK/STAT signaling pathway in red claw crayfish Cherax quadricarinatus, Developmental and Comparative Immunology, 111 (2020) 103749.
Qiu, W.H., Liu, S., Chen, H.H., Luo, S.S., Xiong, H., Xu, B.T.*, Zheng, C.M.*, Wang K.J., The comparative toxicities of BPA, BPB, BPS, BPF, and BPAF on the reproductive neuroendocrine system of zebrafish embryos and its mechanisms, Journal of Hazardous Materials, 406 (2021) 124303.
Cui, Q., Chen, F.Y., Zhang, M., Peng, H., Wang K.J.*, Transcriptomic analysis revealing hepcidin expression in Oryzias melastigma regulated through the JAK-STAT signaling pathway upon exposure to BaP, Aquatic Toxicology, 2019, 206: 134-141.
Qiu, W.H.*, Fang M, Liu J, Fu C, Zheng C, Chen B, Wang K.J.*, In vivo actions of Bisphenol F on the reproductive neuroendocrine system after long-term exposure in zebrafish, Science of the Total Environment, 2019, 665: 995-1002.
Cui, Q., Chen, F.Y., Chen, H.Y., Peng, H., Wang K.J.*, Benzo[a]pyrene (BaP) exposure generates persistent reactive oxygen species (ROS) to inhibit the NF-κB pathway in medaka (Oryzias melastigma)，Environmental Pollution, 2019, 251: 502-509.
Li, M.J., Wang, M., Wang, W.L., Wang L.L., Liu, Z.Q., Sun J.J., Wang K.J.*, Song, L.S.∗, The immunomodulatory function of invertebrate specific neuropeptide FMRFamide in oyster Crassostrea gigas, Fish and Shellfish Immunology, 2019. 88: 480-488.
Chen, F.Y., Wang K.J.*, Characterization of the innate immunity in the mud crab Scylla paramamosain, Fish and Shellfish Immunology, 2019. 93: 436-448.
Bo, J., Y Ying., Zheng R., Fang C., Jiang Y., Liu J., Chen M., Hong F., Bailey C., Segner H., Wang K.J.*, Antimicrobial activity and mechanisms of multiple antimicrobial peptides isolated from rockfish Sebastiscus marmoratus, Fish and Shellfish Immunology, 2019. 93: 1007-1017.
Zhang, M., Zhang, M.F., Chen,F.Y., Cui, Q., Yang, B.Z., Y. Liu, H. Peng, Wang K.J.*, The transcriptional regulation of an antimicrobial peptide hepcidin1 in Oryzias melastigma upon EE2 exposure involved in a new pathway with a novel transcriptional regulatory element HepERE, Fish and Shellfish Immunology, 2018. 82: 421-431.
He, Y.B., Peng, H., Liu, J., Chen, F.Y., Zhou, Y., Ma, X.W., Chen, H.Y., Wang K.J.*, Chlorella sp. transgenic with Scy-hepc enhancing the survival of Sparus macrocephalus and hybrid grouper challenged with Aeromonas hydrophila, Fish and Shellfish Immunology, 2018, 73, 22-29.
Qiu W., Yang M*, Liu S., Lei, P., Hu, Lei., Chen B.,Wu M., Wang K.J.*, Toxic Effects of Bisphenol S Showing Immunomodulation in Fish Macrophages, Environmental Science & Technology, 2018. 52(2): 831-838.
Li, Y.H., Zhuang, S.F., Wu, Y.P., Ren, H.L., Chen, F.Y., Lin, X., Wang K.J.*, John B., Gao, K.S.*, Ocean acidification modulates expression of genes and physiological performance of a marine diatom, PLOS ONE, 2017; 12(2): e0170970.
Ma X.W., Hou, L., Chen, B., Fan, D.Q., Chen, Y.C., Yang, Y., Wang K.J.*, A truncated Sph12-38 with potent antimicrobial activity showing resistance against bacterial challenge in Oryzias melastigma, Fish and Shellfish Immunology, 2017, 67: 561-570.
Qiu, W.H., W M., Liu S., Chen B, Pan C., Yang M*, Wang K.J.*, Suppressive immunoregulatory effects of three antidepressants via inhibition of the nuclear factor-κB activation assessed using primary macrophages of carp (Cyprinus carpio), Toxicology and Applied Pharmacology, 2017, 322, 1-8.
Qiao, K., Xu, W.F., Chen, H.Y., Peng, H., Zhang, Y.Q., Huang, W.S., Wang, S.P., An, Z., Shan, Z.G., Chen, F.Y., Wang K.J.*, A new antimicrobial peptide SCY2 identified in Scylla Paramamosain exerting a potential role of reproductive immunity, Fish and Shellfish Immunology, 2016,51,251-262.
Qiu W., Shen Y., Pan C., Liu S., Wu M., Yang M.*, Wang K.J.*, The potential immune modulatory effect of chronicbisphenol A exposure on gene regulation in male medaka (Oryzias latipes) liver, Ecotoxicology and Environmental Safety, 2016,130, 146-154.
Shan, Z. G., Zhu, K. X., Chen, F. Yi., Liu, J., Chen, B., Qiao, K., Peng, H., Wang K.J.*, In vivo activity and the transcriptional regulatory mechanism of the antimicrobial peptide SpHyastatin in Scylla paramamosain, Fish and Shellfish Immunology, 2016, 59:155-165.
Shan, Z., Peng, H., Zhu, K., Chen, B., Liu, J., Chen F., Ma, X., Wang, S., Kun, Q., Wang K.J.*, The New Antimicrobial Peptide SpHyastatin from Mud Crab Scylla paramamosain with Multiple Antimicrobial Mechanisms and High Effect on Bacterial Infection, Frontiers in Microbiology, 2016, 7:1140.
Chen, B., Fan, DQ., Zhu, KX., Shan, ZG., Chen, FY., Hou, L., Cai, L.，Wang K.J.*, Mechanism study on a new antimicrobial peptide Sphistin derived from the N-terminus of crab histone H2A identified in haemolymphs of Scylla paramamosain, Fish and Shellfish Immunology, 2015, 47, 833-846.
Yang, M.*, Qiu, W., Chen, B., Chen, J., Liu, S., Wu, M., Wang K.J.*, The in vitro immune modulatory effect of bisphenol A on fish macrophages via estrogen receptor α and nuclear factor-κB signaling,Environmental Science & Technology, 2015,49 (3), 1888-1895.
Wang, SP., Chen, FY., Dong, LX., Zhang, YQ., Chen, HY., Qiao, K.,Wang K.J.*, A novel innexin2 forming membrane hemichannel exhibits immune responses and cell apoptosis in Scylla paramamosain, Fish and Shellfish Immunology, 2015, 47, 485-499.
Chen, F.Y., Bo, J., Ma, X.W., Dong, L.X., Shan, Z.G., Cui, Q., Chen, H.Y., Wang K.J.*, A New Membrane Lipid Raft Gene SpFLT-1 Facilitating the Endocytosis of Vibrio alginolyticus in the Crab Scylla paramamosain. PLOS ONE, 2015, 10 (7): e0133443.
Ding, J., Peng, H., Cui, Q., Wang K.J.*, Molecular cloning and characterization of a novel pathogen-induced trypsin-like protease in Scylla paramamosain (Estampador 1949) [J]. Aquaculture Research, 2015, 46(3): 759-764.
Thilagam, H., Gopalakrishnan, S., Bo, J., Wang K.J.*, Comparative study of 17 β-estradiol on endocrine disruption and biotransformation in fingerlings and juveniles of Japanese sea bass Lateolabrax japonicus, Marine Pollution Bulletin, 2014, 85: 332-337.
Zhang, YQ., Qiao, K., Wang, SP., Peng, H., Shan, ZG., Wang K.J.*, Molecular identification of a new androgenic gland-specific insulin-like gene from the mud crab, Scylla paramamosain. Aquaculture, 2014, 433:325-334.
Bo, J., Gopalakrishnan, S., Chen, F.Y., Wang K.J.*, Benzo[a]pyrene modulates the biotransformation, DNA damage and cortisol level of red sea bream challenged with lipopolysaccharide. Marine Pollution Bulletin. 2014,85:463-470.
Mao, M.G.; Jiang, J.L.; Peralvarez-Marin, A; Wang K.J.; Lei, J.L., Characterization of the Mx and hepcidin genes in Epinephelus akaara asymptomatic carriers of the nervous necrosis virus, Aquaculture, 2013, 408:175-183.
Jiang, J.L., Wang, G.Z., Mao, M.G.,Wang K.J., Differential gene expression profile of the calanoid copepod, Pseudodiaptomus annandalei, in response to nickel exposure, Comparative Biochemistry and Physiology, Part C, 2013, 157: 2: 203-211.
Ding, J., Chen, F.Y., Ren, S.Y., Qiao, K., Chen, B., Wang K.J.*, Molecular characterization and promoter analysis of crustacean heat shock protein 10 in Scylla paramemosain, Genome: 2013, 56 (5): 272-81.
Qu, H.D., Chen, B., Peng, Hui., Wang K.J.*, Molecular Cloning, Recombinant Expression and Antimicrobial Activity of EC-hepcidin3, a New Four-cysteine Hepcidin Isoform from Epinephelus coioides, Bioscience, Biotechnology, and Biochemistry, 2013, 77(1):103-110.
Cai, L., Cai, J. J., Liu, H. P., Fan, D. Q., Peng, H., Wang K.J.*, Recombinant medaka (Oryzias melastigma) pro-hepcidin: Multifunctional characterization, Comparative Biochemistry and Physiology, Part B, 2012,161, 140–147.
Peng, H., Liu, H.P., Chen, B., Hao, H., Wang K.J.*, Optimized production of scygonadin in Pichia pastoris and analysis of its antimicrobial and antiviral activities, Protein Expression and Purification, 2012, 82, 37-44.
Bo J, Gopalakrishnan S, Fan DQ, Thilagam H, Qu HD, Zhang N, Chen FY,Wang K.J.*, Benzo[a]pyrene modulation of acute immunologic responses in red sea bream pretreated with lipopolysaccharide. Environmental Toxicology, 2012, 29(5):517-525.
Mao, M.G., Lei, J.L., Alex, P.M., Hong, W.S., Wang K.J.*, Characterization of RAG1 and IgM (mu chain) marking development of the immune system in red-spotted grouper (Epinephelus akaara), Fish and Shellfish Immunology, 2012, 33:725-735.
王克坚，海洋鱼类和青蟹抗菌肽hepcidin和scygonadin的研究，厦门大学学报（自然科学版），2011年3月，第50卷，第2期。
Gopalakrishnan, S., Zhang, N., Thilagam, H., Chen, B., Ding, J., Wang, X.H., Wang, W. X., Ke, C. H., Giesy, J. P., Zhang, X., Wang K.J.*, Biochemical responses and DNA damage in red sea bream from coastal Fujian Province, China, Ecotoxicology and Environmental Safety, 2011, 74, 1526-1535.
Gopalakrishnan, S., Huang, W. B., Wang, Q.W., Wu, M. L., Liu, J., Wang K.J.*, Effects of tributyltin and benzo[a]pyrene on the immune-associated activities of hemocytes and recovery responses in the gastropod abalone, Haliotis diversicolor, Comparative Biochemistry and Physiology, Part C, 2011, 154, 120-128.
Yang, M., Chen, B., Cai, J.J., Peng, H., Cai, L., Yuan, J.J., Wang K.J.*, Molecular characterization of hepcidin AS-hepc2 and AS-hepc6 in black porgy (Acanthopagrus schlegelii):Expression pattern responded to bacterial challenge and in vitro antimicrobial activity. Comparative Biochemistry and Physiology, Part B, 2011; 158:155-163.
Xu, W.F., Qiao, K., Huang, S.P., Huang, S. P., Peng, H., Huang, W.S., Chen, F.Y., Bo, J., Wang K.J.*, Quantitative gene expression and in situ localization of Scygonadin potentially associated with reproductive immunity in tissues of male and female mud crabs, Scylla paramamosain, Fish and Shellfish Immunology, 2011, 31, 243-251.
Xu, W.F., Qiao, K., Huang, S.P., Peng, H., Huang, W.S., Chen, F.Y., Zhang, N., Wang, G.Z., Wang K.J.*, The expression pattern of scygonadin during the ontogenesis of Scylla paramamosain predicting its potential role in reproductive immunity, Developmental & Comparative Immunology, 2011, 35, 1076-1088.
Bo, J., Cai L., Xu J.H, Wang K.J.*, Au, D.*, The marine medaka Oryzias melastigma - a potential marine fish model for innate immune study, Marine Pollution Bulletin, 2011, 63, 267-276.
Liu, H.P. *, Chen, R.Y., Zhang, Q.X., Peng, H., Wang K.J., Differential gene expression profile from haematopoietic tissue stem cells of red claw crayfish, Cherax quadricarinatus, in response to WSSV infection, Developmental & Comparative Immunology, 2011, 35, 716-724.
Gopalakrishnan, S., Chen, F.Y., Thilagam, H., Qiao, K., Xu, W.F., Wang K.J.*, Modulation and interaction of immune-associated parameters with antioxidant in the immunocytes of crab Scylla paramamosain challenged with lipopolysaccharides, Evidence-Based Complementary and Alternative Medicine, 2011, 824962: 1-8.
Thilagam, H., Gopalakrishnan, S., Qu, H.D., Bo, J., Wang K.J.*, 17 β-estradiol induced ROS generation, DNA damage and enzymatic responses in the hepatic tissue of Japanese seabass, Ecotoxicology, 2010,19:1258-1267.
Liu, H.P., Chen, F.Y., Gopalakrishnan, S., Qiao, K., Bo, J.,Wang K.J.*, Antioxidant enzymes from the crab Scylla paramamosain: gene cloning and gene/protein expression profiles against LPS challenge, Fish and Shellfish Immunology, 2010, 28, 862-871.
He, B., Dai, M *, Zhai, W., Wang, L., Wang K.J., Chen, J., Lin, J., Han, A., and Xu, Y., Distribution, degradation and dynamics of dissolved organic carbon and its major compound classes in the Pearl River estuary, China, Marine Chemistry, 2010, 119, 52-64.
Huang, W.B., Ren, H.L., Gopalakrishnan, S., Xu, D.D., Qiao, K., Wang K.J.*, First molecular cloning of a molluscan caspase from variously colored abalone (Haliotis diversicolor) and gene expression analysis with bacterial challenge, Fish and Shellfish Immunology, 2010, 28, 587-595.
Chen, F.Y., Liu, H.P., Bo, J., Ren, H.L., Wang K.J.*, Identification of genes differentially expressed in hemocytes of Scylla paramamosain in response to lipopolysaccharide, Fish and Shellfish Immunology, 2010, 28, 167-177.
Liu, H.P., Chen, R.Y., Zhang, M., Wang K.J., Isolation, gene cloning and expression profile of a pathogen recognition protein: a serine proteinase homolog (Sp-SPH) involved in the antibacterial response in the crab Scylla paramamosain, Developmental & Comparative Immunology, 2010, 34, 741-748.
Peng, H., Yang, M., Huang, W. S., Ding, J., Qu, H.D., Cai, J.J., Zhang, N., Wang K.J.*, Soluble expression and purification of a crab antimicrobial peptide scygonadin in different expression plasmids and analysis of its antimicrobial activity，Protein Expression and Purification, 2010, 70, 109-115.
Onsanit, S., Ke, C., Wang, X., Wang K.J., Wang, W.X *，Trace elements in two marine fish cultured in fish cages in Fujian province, China，Environmental Pollution，2010, 158(5), 1334-1342.
Wang K.J.*, Cai, J.J., Cai, L., Qu, H.D.,Yang, M., Zhang, M., Cloning and expression of a hepcidin gene from a marine fish (Pseudosciaena crocea) and the antimicrobial activity of its synthetic peptide. Peptides, 2009, 30: 638-646.
Thilagam, H., Gopalakrishnan, S., Bo, J., Wang K.J.*, Effect of 17beta-estradiol on the immunocompetence of Japanese sea bass (Lateolabrax japonicus), Environmental Toxicology and Chemistry, 2009, 28 (8): 1722-1731.
Ren, H.L., Xu, D.D., Gopalakrishnan, S., Qiao, K., Huang, W.B., Wang K.J.*, Gene cloning of a sigma class glutathione S-transferase from abalone (Haliotis diversicolor) and expression analysis upon bacterial challenge, Developmental & Comparative Immunology, 2009, 33, 980-990.
Wang K.J.*, Bo, J., Yang, M., Hong, H.S., Wang, X.H., Chen, F.Y., Yuan, J.J., Hepcidin gene expression induced in the developmental stages of fish upon exposure to Benzo[a]pyrene (BaP), Marine Environmental Research, 2009, 69: 159-165.
Gopalakrishnan, S., Thilagam, H., Huang,W.B., Wang K.J.*, Immunomodulation in the marine gastropod Haliotis diversicolor exposed to Benzo(a)pyrene. Chemosphere, 2009, 75: 389-397.
Xu, X.J., Wang, G.Z., Wang K.J., Li, S.J. Isolation and characterization of ten new polymorphic microsatellite loci in the mud crab, Scylla paramamosain, Conserv Genet, 2009, 10: 1877-1878.
任洪林，柳增善，王克坚*，鲍免疫相关基因和蛋白的研究进展，遗传（综述），2009年4月, 31(4): 348-358。
任洪林, 徐丹丹, 乔琨, 蔡灵, 黄伟滨, 张鼐, 王克坚*，细菌攻毒杂色鲍血淋巴细胞抑制性差减杂交文库构建及巨噬细胞表达蛋白 cDNA 的克隆与差异表达，遗传（研究报告），2008 年 8 月, 30(8): 1043-1050。
Wang K.J.*, Ren, H.L., Xu, D.D., Cai, L., Yang, M., Identification of the up-regulated expression genes in hemocytes of Variously Colored Abalone (Haliotis diversicolor Reeve, 1846) challenged with bacteria, Developmental & Comparative Immunology, 2008, 32: 1326-1347.
Wang K.J.*, Huang, W.S., Yang, M., Chen, H.Y., Bo, J., Li, S. J., Wang G.Z., A male-specific expression gene, encodes a novel anionic antimicrobial peptide, scygonadin, in Scylla serrata. Molecular Immunology, 2007, 44: 1961-1968.
Wang, G.Z.*, Kong, X.H., Wang K.J., Li, S.J., Variation of specific proteins, mitochondria and fatty acid composition in gill of Scylla serrata (Crustacea, Decapoda) under low temperature adaptation, Journal of Experimental Marine Biology and Ecology, 2007, 352:1326-1347.
Yang, M., Wang K.J.*, Chen, J.H., Qu, H.D., Li, S. J., Genomic organisation and tissue-specific expression analysis of Hepcidin-like genes from black porgy (Acanthopagrus schlegelii B.), Fish and Shellfish Immunology, 2007, 23:1060-1071.
黄文树，李少菁，蔡灵，杨明，陈君慧，王克坚∗，尼罗罗非鱼Hepcidin基因结构与序列分析，厦门大学学报（自然科学版），2007年5月，第46卷，第3期。
Huang, W.S.,Wang K.J.*, Yang, M., Cai J.J., Li S. J., Wang, G.Z., Purification and part characterization of a novel antibacterial protein Scygonadin, isolated from the seminal plasma of mud crab, Scylla serrata ((Forkal , 1775), Journal of Experimental Marine Biology and Ecology, 2006, 399:37-42.
Ren, H.L., Wang K.J.*, Zhou, H.L., Yang, M., Cloning and organization analysis of a hepcidin-like gene and cDNA from Japan sea bass, Lateolabrax japonicus, Fish and Shellfish Immunology, 2006,21: 221-227.
王克坚，周红玲，杨明，海水养殖鲈鱼分离出一种 hepcidin抗菌肽新基因，厦门大学学报（自然科学版），2005年5月，第43卷，第3期。

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