陈铭 Ming Chen

个人履历 Brief CV

1998年9月—2002年7月：北京大学，药学院，药学学士 B.Sc. in Pharmaceutical sciences, Peking University, China
2002年8月-2003年8月: 瑞士Basilea Pharmaceutical AG中国，实验室研究员 Basilea Pharmaceutical AG，China，Researcher
2004年9月—2007年7月：北京大学，药学院，药剂学硕士 M.Sc. in Pharmaceutics, Peking University, China
2007年9月—2011年5月：德国耶拿大学，药剂系，药剂学博士 Ph.D. in Pharmaceutics, Friedrich-Schiller-Universität Jena, Germany
2011年8月—2014年6月: 美国加州大学圣芭芭拉分校，化学/生物工程中心，博士后 Post-Doc, University of California, Santa Barbara, USA
2015年4月---2021年12月：厦门大学，海洋与地球学院，副教授 Associate Professor, Xiamen University, China
2022年1月---至今：厦门大学，海洋与地球学院，教授 Professor, Xiamen University, China

研究方向 Research Interests

1.海洋生物医学材料 Marine Biomedical Materials
2.经皮给药技术 Skin Drug Delivery
3.海洋生物制药 Marine biopharmaceutic

代表性论文 Selected Publications

1. XueJiao Liang, Jialiang Zhang, HuiLong Ou, Jun，Samir Mitragotri, Ming Chen*.Skin delivery of siRNA using sponge spicules in combination with cationic flexible liposomes. Molecular Therapy - Nucleic Acid. 2020. In press. doi.org/10.1016/j.omtn.2020.04.003
2. Keda Zhang, Li Yu, Fu-Rong Li, Xue Li, Zhefeng Wang, Xiaoting Zou, Chi Zhang, Kongpeng Lv, Boping Zhou, Samir Mitragotri and Ming Chen*.Topical Application of Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells in Combination with Sponge Spicules for Treatment of Photoaging. International Journal of Nanomedicine. 2020:15,1-14.
3. XueKe Lin, ZhenHua Wang, Huilong Ou, Samir Mitragotri, Ming Chen*. Correlations between skin barrier integrity and delivery of hydrophilic molecules in the presence of penetration enhancers, Pharmaceutical Research. 2020. doi.org/10.1007/s11095-020-02800-4
4. Keda Zhang, Wanyang Sun, Alfred Fahr, Xiaobin Zeng,Lanlan Ge, Ming Chen*,Lingzhi Yang, Shipin Wu, Jia Fei and Boping Zhou. Skin-permeating components of Lonicera japonica flos: a comprehensive study from observations and model computations. New J. Chem., 2019, 43, 12538
5. Chi Zhang, Keda Zhang, Jialiang Zhang, Huilong Ou, Jiwen Duan, Saiman Zhang, Dexiang Wang, Samir Mitragotri, Ming Chen*.Skin delivery of hyaluronic acid by the combined use of sponge spicules and flexible liposomes. Biomater Sci. 2019 Mar 26;7(4):1299-1310
6. Xiaobin Zeng, Zhefeng Wang, Xiangli Liu, Ming Chen*, Alfred Fahr and Keda Zhang.Predicting the skin-permeating components of externally-applied medicinal herbs: application of a newly constructed linear free-energy relationship equation for human skin permeation.New J. Chem., 2018, 42, 11930
7. Saiman Zhang, Huilong Ou, Chunyun Liu, Yuan Zhang, Samir Mitragotri, Dexiang Wang, and Ming Chen*. Skin Delivery of Hydrophilic Biomacromolecules Using Marine Sponge Spicules. Mol. Pharmaceutics 2017, 14, 3188−3200.
8. Ming Chen, Sunny Kumar, Aaron C. Anselmo, Vivek Gupta, Deborah H. Slee, John A. Muraski, Samir Mitragotri. Topical delivery of Cyclosporine A into the skin using SPACE-peptide. Journal of controlled release, 199 (2015) 190-197.
9. Ming Chen, Sunny Kumar,Aaron A Anselmo, John A Muraski and Samir Mitragotri,Enhanced Dermal Retention of Topically Applied Steroids using SPACE Peptide. Drug Deliv Transl Res. 2015 May 5. [Epub ahead of print]
10. Sunny Kumar, Ming Chen, Michael Zakrewsky, Stefano Menegatti, and John A Muraski, Samir Mitragotri. Mechanisms of Peptides as Skin Penetration Enhancers. Journal of controlled release, 199 (2015) 168–178.
11. M. Chen, M. Zakrewsky, V. Gupta, A.C. Anselmo, D.H. Slee, J.A. Muraski, S. Mitragotri, Topical delivery of siRNA into skin using SPACE-peptide carriers, Journal of controlled release, 179C (2014) 33-41.
12. M. Chen, V. Gupta, A.C. Anselmo, J.A. Muraski, S. Mitragotri, Topical delivery of hyaluronic acid into skin using SPACE-peptide carriers, Journal of Controlled Release, 173 (2014) 67-74.
13. Anselmo, A.C., Modery-Pawlowski, C.L., Menegatti, S., Kumar, S., Vogus, D.R., Tian, L.L., Chen, M., Squires, T.M., Gupta, A.S., and Mitragotri, S., "Platelet-like Nanoparticles (PLNs): Engineering Shape, Flexibility and Surface Chemistry of Nanocarriers to Target Vascular Injuries", ACS Nano, Epub (2015).
14. Zhang K, Chen M, Scriba GK, Abraham MH, Fahr A, Liu X.Human skin permeation of neutral species and ionic species: extended linear free-energy relationship analyses.J Pharm Sci. 2012 Jun;101(6):2034-44.
15. Haag SF, Chen M, Peters D, Keck CM, Taskoparan B, Fahr A, Teutloff C, Bittl R,Lademann J, Schäfer-Korting M, Meinke MC. Nanostructured lipid carriers as nitroxide depot system measured by electron paramagnetic resonance spectroscopy.Int J Pharm. 2011 Dec 15;421(2):364-9. Epub 2011 Oct 6. PMID:22001533
16. Haag SF, Fleige E, Chen M, Fahr A, Teutloff C, Bittl R, Lademann J, Schäfer-Korting M, Haag R, Meinke MC. Skin penetration enhancement of core-multishell nanotransporters and invasomes measured by electron paramagnetic resonance spectroscopy. Int J Pharm. 2011 Sep 15;416(1):223-8. Epub 2011 Jul 1.PMID: 21745556
17. Yang K, Gitter B, Rüger R, Wieland GD, Chen M, Liu X, Albrecht V, Fahr A. Antimicrobial peptide-modified liposomes for bacteria targeted delivery of temoporfin in photodynamicantimicrobial chemotherapy. Photochem Photobiol Sci. 2011 Oct;10(10):1593-601. Epub 2011 Jul 20. PMID: 21773628
18. Keda Zhang, Ming Chen, Gerhard Scriba, Micheal H. Abraham, Afred Fahr, Xiangli Liu. Linear Solvation Energy Relationship (LSER) Analysis of Retention Factors in Cerasome Electrokinetic Chromatography (EKC). Journal of pharmaceutical science, 2011, Mar 31. doi: 10.1002/jps.22549.
19. Ming Chen, Xiangli Liu, Alfred Fahr. Skin penetration and deposition of Carboxyfluorescein and Temoporfin from different lipid vesicles: In vitro study with finite and infinite dosage application. International journal of Pharmaceutics, 2011, Vol.408, 223–234.
20. S. F. Haag, M. Chen, B. Taskoparan, A. Fahr, R. Bittl, C. Teutloff, R. Wenzel, J. Lademann, M. Schäfer-Korting, M. C. Meinke. Stabilization of reactive nitroxides using invasomes to allow prolonged EPR measurements. Skin Pharmacology & Physiology, 2011;24(6):312-21. doi: 10.1159/000330235.
21. Ming Chen, Xiangli Liu, Alfred Fahr. Skin delivery of ferulic acid from different lipid vesicular systems. Journal of Biomedical Nanotechnology, 2010 Oct; 6(5):577-85.
22. Liu, X., Fan, P. Chen, M., Hefesha, H., Scriba, G.K.E., Gabel D. & Fahr, A.: Drug -membrane interaction on immobilized liposome chromatography compared to Immobilized Artificial Membrane (IAM), liposome/water, and octan-1-ol/water systems, Helv. Chim. Acta 93, 203-211, 2010
23. Alfred Fahr, Ming Chen. 2010. Liposomes as Promising Tools for the Skin Delivery and Protection of Damaged Skin, in: Monteiro-Riviere, N.A. (Ed.), Toxicology of the Skin, First ed. informa healthcare.
24. Chen M, Li XR, Zhou YX, Yang KW, Chen XW, Deng Q, Liu Y, Ren LJ.Improved absorption of salmon calcitonin by ultraflexible liposomes through intranasal delivery. Peptides. 2009 Jul; 30(7):1288-95.
25. Chen M, Deng Q, Li XR, Liu Y.The hypocalcemia effect of salmon calcitonin ultra-flexible liposomes after intranasal administration in rats.Acta Pharmaceutica Sinica. 2007 Jun; 42(6):681-6.

专利 Patent

1. US2014/0227172 A1（已授权，美国）
2. WO 2014/123543 A2&A3
3. CN201710666564.2
4. CN201880000113.8
5. CN201610267935.5
6. ZL201610267764.6（已授权，中国）
7. CN201910958941.9
8. CN201911347585.3
9. CN201811175149.8
10. CN201910641196.5
11. CN201910619867.8
12. PCT/CN2019/108876
13. PCT/CN2019/096166
14. PCT/CN2018/077288
15. PCT/CN2017/081167
16. PCT/CN2020/073345
17. US 16/028,036（已授权，美国）
18. CN201910019931.9
19. CN202010087124.3

主要教学：

分子生物学（大三，春季学期）

海生技专门化实验（大三，春节学期）

海洋药物及海洋生物医学材料概论（大二小学期）

海洋生物资源与生物技术（硕博通修，秋季学期）

指导学生：

刘春云，博士生       2016级
张驰，博士生        2019级
范馨莉，硕士生       2014级
何韦宜，硕士生       2015级
张驰，硕士生       2016级
林雪柯，硕士生       2016级
段继雯，硕士生       2016级
梁雪娇，硕士生       2017级
翟浩洁，硕士生       2018级
陈雪，硕士生       2019级
卢小凤，本科生       2013级
罗云柯，本科生       2013级
郑仪，本科生       2014级
邱婕，本科生     2015级
       林琪凡，本科生   2015级
黄琳洁，本科生   2015级
张琪，本科生     2015级
李春锦，本科生   2015级
吴琼珑，本科生   2015级
邹仁彬，本科生       2015级
       李诗梦，本科生       2016级
李泓霖，本科生       2019级
姚伟汉，本科生（访问）     2016级厦门大学马来西亚校区

学术任职职和奖励：

厦门市引进海外高层次人才（2016年）

福建省引进海外高层次人才（2017年）

福建省引才“百人计划”（2018年）

Journal of Controlled Release杰出审稿人

Journal of Herbal Medicine审稿人

美国细胞与基因治疗协会（ASGCT）会员（2020-）

厦门大学海洋与地球学院2018年教学大赛青年教师教学技能比赛，一等奖

厦门大学2019年“曹德旺奖教金”

2019年德贞社会课堂基金，优秀指导教师

第五届福建省“互联网+”大学生创新创业大赛，优秀指导老师

厦门大学D²S²课题组（Deep Sea & Deep Skin Lab）。本课题组主要从事海洋（Deep Sea）和皮肤（Deep Skin）领域的交叉学科研究。海洋是地球上生物资源丰富的领域，海洋生物资源的高效、深层次开发利用，对于促进我国海洋生物资源开发利用水平，推动“蓝色”经济的发展具有重要的意义。另一方面，皮肤是一种生物膜屏障，除了极少数的分子可以通过皮肤角质层屏障，绝大部分的药物分子很难通过角质层屏障被吸收。课题组目前聚焦在海洋生物医用材料和皮肤给药技术的研究，从不同角度把两个不同领域的研究有机结合在一起。

师资力量

师资队伍